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National Chung Hsing University Institutional Repository - NCHUIR > 獸醫學院 > 獸醫學系所 > 依資料類型分類 > 期刊論文 >  The Activity of Plasma Matrix Metalloproteinase-9 as a Marker to Reflect the Tissue Level of Mammary Glands Tumor in Dogs

Please use this identifier to cite or link to this item: http://nchuir.lib.nchu.edu.tw/handle/309270000/126078

標題: The Activity of Plasma Matrix Metalloproteinase-9 as a Marker to Reflect the Tissue Level of Mammary Glands Tumor in Dogs
作者: Shia, Wei-Yau;Liu, Shih-Ming;Lee, Chun-Sheng;Lin, Jian-Liang;Chou, Chih-Chung;Yuasa, Yumi;Chang, Shih-Chieh;Lee, Wei-Ming
Contributors: 國立中興大學獸醫系
National Chung Hsing University,Department of Veterinary Medicine
Miao-zhen Luo
關鍵字: dog;mammary tumor;matrix metalloproteinase;matrix-metalloproteinase (mmp)-2;cancer-patients;breast-cancer;mmp-9;activities;iv collagenase;gelatinase-a;metastasis;adenocarcinoma;expression;mechanisms
日期: 2011-3
Issue Date: 2012-10-19 15:12:23 (UTC+8)
摘要: In order to understand the change of MMP-2 and MMP-9 in dogs with mammary gland tumor (MGT), the activity of MMP-2 and MMP-9 in plasma samples, MGT tissues and near by normal mammary gland tissues were evaluated by gelatin zymography. The levels of MMP-2 and MMP-9 were significantly higher in tumor tissues than those in normal gland tissues (p<0.05). Plasma MMP-9 levels in malignant cases were higher than those in benign (p=0.15) and non-tumor cases (p<0.05). Likewise, plasma MMP-2 levels in malignant MGT cases were higher than non-tumor (p<0.01) and benign cases (p=0.54)). Furthermore, plasma MMP-9 levels were reflected and positively correlated with MMP-9 in tumor tissues (r=0.78, p=0.02), but not MMP-2. Our results indicated that the MMP-2 and MMP-9 levels are associated with tumor malignancy, and plasma MMP-9 activity can become a potential marker both in follow-up and prognosis of canine MGT patients.
Relation: Thai Journal of Veterinary Medicine, Volume 41, Issue 1, Page(s) 111-117.
Appears in Collections:[依資料類型分類] 期刊論文
[依教師分類] 張仕杰
[依教師分類] 李衛民
[依教師分類] 張仕杰
[依教師分類] 李衛民

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