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National Chung Hsing University Institutional Repository - NCHUIR > 工學院 > 化學工程學系所 > 依資料類型分類 > 期刊論文 >  Cytotoxicity and Immunological Response of Gold and Silver Nanoparticles of Different Sizes

Please use this identifier to cite or link to this item: http://nchuir.lib.nchu.edu.tw/handle/309270000/129107

標題: Cytotoxicity and Immunological Response of Gold and Silver Nanoparticles of Different Sizes
作者: Yen, H.J.;Hsu, S.H.;Tsai, C.L.
關鍵字: cytotoxicity;gold;immunological response;nanoparticles;silver;receptor-mediated endocytosis;in-vitro cytotoxicity;mammalian-cells;macrophage;adsorption;toxicity;dna;biocompatibility;microspheres;phagocytosis
日期: 2009
Issue Date: 2012-12-07 15:20:33 (UTC+8)
關連: Small, Volume 5, Issue 13, Page(s) 1553-1561.
摘要: The immunological response of macrophages to physically produced pure Au and Ag nanoparticles (NPs) (in three different sizes) is investigated in vitro. The treatment of either type of NP at >= 10 ppm dramatically decreases the population and increases the size of the macrophages. Both NPs enter the cells but only AuNPs (especially those with smaller diamter) tip-regulate the expressions of proinflammatory genes interlukin-1 (IL-1), interlukin-6 (IL-6), and tumor necrosis factor (TNF-alpha). Transmission electron microscopy images show that AuNPs and AgNPs are both trapped in vesicles in the cytoplasma, but only AuNPs are organized into a circular pattern. It is speculated that part of the negatively charged AuNPs might adsorb serum protein and enter cells via the more complicated endocytotic pathway, which results in higher cytotoxicity and immunological response of AuNPs as compared to AgNPS.
Relation: Small
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