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National Chung Hsing University Institutional Repository - NCHUIR > 生命科學院 > 生命科學院 > 依資料類型分類 > 期刊論文 >  Cilostazol Ameliorates Nephropathy in Type 1 Diabetic Rats Involving Improvement in Oxidative Stress and Regulation of TGF-beta and NF-kappa B

Please use this identifier to cite or link to this item: http://nchuir.lib.nchu.edu.tw/handle/309270000/130697

標題: Cilostazol Ameliorates Nephropathy in Type 1 Diabetic Rats Involving Improvement in Oxidative Stress and Regulation of TGF-beta and NF-kappa B
作者: Lee, W.C.;Chen, H.C.;Wang, C.Y.;Lin, P.Y.;Ou, T.T.;Chen, C.C.;Wen, M.C.;Wang, J.;Lee, H.J.
關鍵字: cilostazol;oxidative stress;diabetic nephropathy;TGP-beta;NF-kappa B;renal-disease;phosphodiesterase inhibitor;activation;hypertrophy;expression;cells;mice;camp
日期: 2010
Issue Date: 2012-12-07 16:05:35 (UTC+8)
關連: Bioscience Biotechnology and Biochemistry, Volume 74, Issue 7, Page(s) 1355-1361.
摘要: Diabetic nephropathy is characterized as the progressive development of renal insufficiency in a setting of hyperglycemia. Previous studies indicate that reactive oxygen species (ROS) play an important role in high glucose-induced renal injury. Cilostazol was reported to lower the production of superoxide significantly in situ. We hypothesized that cilostazol administration in streptozotocin-induced diabetic rats exerts effects via improving oxidative stress. Male Sprague Dawley rats were fed with cilostazol (5 mg/kg or 25 mg/kg) for 12 weeks after streptozotocin-induced diabetes mellitus. The results showed that cilostazol decreased reactive oxygen species activity significantly in the kidneys of diabetic rats and improved the urine albumin/creatinine ratio. Cilostazol can also improve the levels of serum cholesterol, triglyceride, and LDL-cholesterol. Additionally, diabetes-caused increased glomerular size, TGF-beta, and NF-kappa B decreased under treatment with cilostazol in diabetic rats. Our results indicate that cilostazol has beneficial effects in early diabetic nephropathy.
Relation: Bioscience Biotechnology and Biochemistry
Appears in Collections:[依資料類型分類] 期刊論文
[依教師分類] 陳鴻震
[依教師分類] 陳鴻震

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