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National Chung Hsing University Institutional Repository - NCHUIR > 生命科學院 > 生命科學院 > 依資料類型分類 > 期刊論文 >  Essential role of PKC delta in histone deacetylase inhibitor-induced Epstein-Barr virus reactivation in nasopharyngeal carcinoma cells

Please use this identifier to cite or link to this item: http://nchuir.lib.nchu.edu.tw/handle/309270000/130722

標題: Essential role of PKC delta in histone deacetylase inhibitor-induced Epstein-Barr virus reactivation in nasopharyngeal carcinoma cells
作者: Lee, H.H.;Chang, S.S.;Lin, S.J.;Chua, H.H.;Tsai, T.J.;Tsai, K.;Lo, Y.C.;Chen, H.C.;Tsai, C.H.
陳鴻震
關鍵字: protein-kinase-c;sarcoma-associated herpesvirus;lytic cycle;sp1;sites;activation mechanisms;signaling pathway;expression;induction;promoter;gene
日期: 2008
Issue Date: 2012-12-07 16:06:08 (UTC+8)
關連: Journal of General Virology, Volume 89, Page(s) 878-883.
摘要: Histone deactylase inhibitors (HDACi) are common chemotherapeutic agents that stimulate Epstein-Barr virus (EBV) reactivation; the detailed mechanism remains obscure. In this study, it is demonstrated that PKC delta is required for induction of the EBV lytic cycle by HDACi. Inhibition of PKC delta abrogates HDACi-mediated transcriptional activation of the Zta promoter and downstream lytic gene expression. Nuclear translocation of PKC delta is observed following HDACi stimulation and its overexpression leads to progression of the EBV lytic cycle. Our study suggests that PKC delta is a crucial mediator of EBV reactivation and provides a novel insight to study the regulation of the EBV lytic cycle.
Relation: Journal of General Virology
Appears in Collections:[依資料類型分類] 期刊論文
[依教師分類] 陳鴻震
[依教師分類] 陳鴻震

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