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National Chung Hsing University Institutional Repository - NCHUIR > 生命科學院 > 生命科學院 > 依資料類型分類 > 期刊論文 >  Effect of aristolochic acid on intracellular calcium concentration and its links with apoptosis in renal tubular cells

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標題: Effect of aristolochic acid on intracellular calcium concentration and its links with apoptosis in renal tubular cells
作者: Hsin, Y.H.;Cheng, C.H.;Tzen, J.T.C.;Wu, M.J.;Shu, K.H.;Chen, H.C.
關鍵字: aristolochic acid;apoptosis;calcium;ER stress;GRP78;kidney;mitochondrial permeability transition;chinese herbs nephropathy;unfolded protein response;endoplasmic-reticulum;epithelial-cells;cyclosporine-a;ca2+ stores;nf-at;death;stress
日期: 2006
Issue Date: 2012-12-07 16:06:24 (UTC+8)
關連: Apoptosis, Volume 11, Issue 12, Page(s) 2167-2177.
摘要: Aristolochic acid (AA) has been demonstrated to play a causal role in Chinese herbs nephropathy. However, the detailed mechanism for AA to induce apoptosis of renal tubular cells remains obscure. In this study, we show that AA evokes a rapid rise in the intracellular Ca2+ concentration of renal tubular cells through release of intracellular endoplasmic reticulum Ca2+ stores and influx of extracellular Ca2+, which in turn causes endoplasmic reticulum stress and mitochondria stress, resulting in activation of caspases and finally apoptosis. Ca2+ antagonists, including calbindin-D-28k (an intracellular Ca2+ buffering protein) and BAPTA-AM (a cell-permeable Ca2+ chelator), are capable of ameliorating endoplasmic reticulum stress and mitochondria stress, and thereby enhance the resistance of the cells to AA. Moreover, we show that overexpression of the anti-apoptotic protein Bcl-2 in combination with BAPTA-AM treatment can provide renal tubular cells with almost full protection against AA-induced cytotoxicity. In conclusion, our results demonstrate an impact of AA to intracellular Ca2+ concentration and its link with AA-induced cytotoxicity.
Relation: Apoptosis
Appears in Collections:[依資料類型分類] 期刊論文
[依教師分類] 曾志正
[依教師分類] 陳鴻震
[依教師分類] 陳鴻震

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