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National Chung Hsing University Institutional Repository - NCHUIR > 學術研究中心 > 生物科技發展中心 > 依資料類型分類 > 期刊論文 >  Continuous lipase-catalyzed synthesis of hexyl laurate in a packed-bed reactor: optimization of the reaction conditions in a solvent-free system

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標題: Continuous lipase-catalyzed synthesis of hexyl laurate in a packed-bed reactor: optimization of the reaction conditions in a solvent-free system
作者: Ju, H.Y.;Yang, C.K.;Yen, Y.H.;Shieh, C.J.
關鍵字: continuous;hexyl laurate;packed-bed reactor;response surface;solvent-free;acid;esters;column;oil
日期: 2009
Issue Date: 2012-12-07 16:12:16 (UTC+8)
關連: Journal of Chemical Technology and Biotechnology, Volume 84, Issue 1, Page(s) 29-33.
摘要: BACKGROUND: Hexyl laurate has been applied widely in cosmetic industries and is synthesized by chemical methods with problems of cost, environmental pollution, and by-products. In this study, Lipozyme (R) IM77 (from Rhizomucor miehei) was used to catalyze the direct-esterification of hexanol and lauric acid in a solvent-free system by utilizing a continuous packed-bed reactor, wherein the aforementioned difficulties could be overcome. Response surface methodology (RSM) and three-level-three-factor Box-Behnken design were employed to evaluate the effects of synthesis parameters, such as reaction temperature (45-65 degrees C), mixture flow rate (0.25-0.75 mL min(-1)) and concentration of lauric acid (1100-300 mmol L(-1)) on the production rate (mu mol min(-1)) of hexyl laurate by direct esterification. RESULTS: The production rate was affected significantly by the mixture flow rate and lauric acid concentration. On the basis of ridge-max analysis, the optimum synthesis conditions for hexyl laurate were as follows: 81.58 +/- 1.76 mu mol min(-1) at 55 degrees C, 0.5 mL min(-1) flow rate and 0.3 mol L(-1) lauric acid. CONCLUSION: The lipase-catalyzed synthesis of hexyl laurate by Lipozyme (R) IM-77 in a continuous packed-bed bioreactor and solvent-free system was successfully developed; optimization of the reaction parameters was obtained by Box-Behnken design and RSM. (C) 2008 Society of Chemical Industry
Relation: Journal of Chemical Technology and Biotechnology
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