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National Chung Hsing University Institutional Repository - NCHUIR > 學術研究中心 > 生物科技發展中心 > 依資料類型分類 > 期刊論文 >  Optimized synthesis of lipase-catalyzed L-ascorbyl laurate by Novozymo (R) 435

Please use this identifier to cite or link to this item: http://nchuir.lib.nchu.edu.tw/handle/309270000/130979

標題: Optimized synthesis of lipase-catalyzed L-ascorbyl laurate by Novozymo (R) 435
作者: Chang, S.W.;Yang, C.J.;Chen, F.Y.;Akoh, C.C.;Shieh, C.J.
謝淳仁
關鍵字: Antioxidant;Ascorbyl esters;Lipase;Optimization;Response surface;methodology;fatty-acid esters;enzymatic-synthesis;organic media;vitamin-c;linoleate
日期: 2009
Issue Date: 2012-12-07 16:12:18 (UTC+8)
關連: Journal of Molecular Catalysis B-Enzymatic, Volume 56, Issue 1, Page(s) 7-12.
摘要: L-Ascorbyl laurate is a fatty acid derivative Of L-ascorbic acid which can be widely used as a natural antioxidant in both lipid containing food and cosmetic applications. To avoid any possible harmful effects from chemically synthesized product, the enzymatic synthesis appears to be the best way to satisfy the consumer demand for natural antioxidants. The ability of immobilized lipase from Candida antarctica (Novozym (R) 435) to catalyze the direct esterification between L-ascorbic acid and lauric acid was investigated. Response Surface methodology (RSM) and 5-level-4-factor central composite rotatable design (CCRD) were employed to evaluate the effects of synthesis parameters, such as reaction time (2-10h), temperature (25-65 C), enzyme amount (10-50% w/w of L-ascorbic acid), and substrate molar ratio of L-ascorbic acid to lauric acid (1:1-1:5) on percentage molar conversion to L-ascorbyl laurate. Based on the analysis result of ridge max, the optimal enzymatic synthesis conditions were predicted as follows: reaction time 6.7 h, temperature 30.6 C, enzyme amount 34.5%, substrate molar ratio 1:4.3: and the optimal actual yield was 93.2%. (C) 2008 Elsevier B.V. All rights reserved.
Relation: Journal of Molecular Catalysis B-Enzymatic
Appears in Collections:[依資料類型分類] 期刊論文

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