English  |  正體中文  |  简体中文  |  Items with full text/Total items : 43312/67235
Visitors : 2020945      Online Users : 4
RC Version 5.0 © Powered By DSPACE, MIT. Enhanced by NTU/NCHU Library IR team.

Please use this identifier to cite or link to this item: http://nchuir.lib.nchu.edu.tw/handle/309270000/131265

標題: Antiviral therapy targeting viral polymerase
作者: Tsai, C.H.;Lee, P.Y.;Stollar, V.;Li, M.L.
蔡慶修
關鍵字: hepatitis-c virus;herpes-simplex-virus;hiv-1 reverse-transcriptase;dependent rna-polymerase;cytomegalovirus dna-polymerase;varicella-zoster-virus;decreased replication capacity;nonstructural 5a;protein;double-stranded dna;p-gene-product
日期: 2006
Issue Date: 2012-12-07 16:21:20 (UTC+8)
關連: Current Pharmaceutical Design, Volume 12, Issue 11, Page(s) 1339-1355.
摘要: Viral DNA and RNA polymerases are enzymes, which are responsible for copying the genetic materials of viruses and are therefore central components in the life cycles of viruses. The polymerases are essentially required for the replication of viruses. The reverse transcriptase (RT) of the retroviruses and the hepadnaviruses is the sole viral enzyme required for the synthesis of DNA from viral RNA. Viral polymerases are therefore an extremely favorable target for the development of antiviral therapy. The success of anti-HIV-1 therapy using inhibitors specifically targeting HIV RT suggests that other viral polymerases can be the valid molecular targets for the design of antiviral drugs. Intensive structural and functional studies of viral polymerases have been conducted and have opened new avenues for the development of more effective antiviral therapy. This review summarizes the insights gained from recent structural and functional studies of antiviral agents, which target viral polymearses. The primary focus will be on hepatitis C virus (HCV), herpesviruses, HIV, hepatitis B virus (HBV) and influenza virus.
Relation: Current Pharmaceutical Design
Appears in Collections:[依資料類型分類] 期刊論文
[依教師分類] 蔡慶修

loading Web of Knowledge data....

Files in This Item:

File SizeFormat
index.html0KbHTML357View/Open


 


學術資源

著作權聲明

本網站為收錄中興大學學術著作及學術產出,已積極向著作權人取得全文授權,並盡力防止侵害著作權人之權益。如仍發現本網站之數位內容有侵害著作權人權益情事者,請權利人通知本網站維護人員,將盡速為您處理。

本網站之數位內容為國立中興大學所收錄之機構典藏,無償提供學術研究與公眾教育等公益性使用。

聯絡網站維護人員:wyhuang@nchu.edu.tw,04-22840290 # 412。

DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU/NCHU Library IR team Copyright ©   - Feedback