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National Chung Hsing University Institutional Repository - NCHUIR > 農業暨自然資源學院 > 昆蟲學系 > 依資料類型分類 > 期刊論文 >  Angiostrongylus cantonensis: Efficacy of albendazole-dexamethasone co-therapy against infection-induced plasminogen activators and eosinophilic meningitis

Please use this identifier to cite or link to this item: http://nchuir.lib.nchu.edu.tw/handle/309270000/132537

標題: Angiostrongylus cantonensis: Efficacy of albendazole-dexamethasone co-therapy against infection-induced plasminogen activators and eosinophilic meningitis
作者: Tu, W.C.;Lai, S.C.
杜武俊
關鍵字: tissue-type plasminogen activator;urokinase-type plasminogen activator;Angiostrongylus cantonensis;meningitis;dexamethasone;cerebrospinal-fluid;bacterial-meningitis;flow-rate;blood;mice;csf;meningoencephalitis;neurocysticercosis;immunoglobulins;praziquantel
日期: 2006
Issue Date: 2012-12-07 17:03:45 (UTC+8)
關連: Experimental Parasitology, Volume 113, Issue 1, Page(s) 8-15.
摘要: Angiostrongyliasis is one of the common causes leading to eosinophilic meningitis. Tissue-type plasminogen activator (tPA) and urokinase-type plasminogen activator (uPA) may play a role in the pathogenesis. Administration of steroid drugs has been reported to possibly relieve the symptoms of eosinophilic meningitis. This study evaluates the curative effects of albendazole-dexamethasone co-therapy on eosinophilic meningitis in BALB/c mice. Assay indicators for the therapeutic effect include worm recovery, histopathological score of meningitis, tPA, uPA, total protein, and leukocyte counts. The results show that the albendazole-dexamethasone co-therapy significantly decreased (P < 0.05) these factors after treatment on day 5 post-inoculation (PI), in contrast to treatment on 15 PI. Thus, the timing of medication is important and is closely related to the anthelmintic efficacy of a drug. At the same dosage and days post-infection. the earlier administration shows better results. This study showed that albendazole-dexamethasone co-therapy is an effective approach for the treatment of parasitic meningitis. (c) 2005 Elsevier Inc. All rights reserved.
Relation: Experimental Parasitology
Appears in Collections:[依資料類型分類] 期刊論文
[依教師分類] 杜武俊
[依教師分類] 杜武俊

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