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National Chung Hsing University Institutional Repository - NCHUIR > 農業暨自然資源學院 > 昆蟲學系 > 依資料類型分類 > 期刊論文 >  Association of matrix metalloproteinase-9 and Purkinje cell degeneration in mouse cerebellum caused by Angiostrongylus cantonensis

Please use this identifier to cite or link to this item: http://nchuir.lib.nchu.edu.tw/handle/309270000/132588

標題: Association of matrix metalloproteinase-9 and Purkinje cell degeneration in mouse cerebellum caused by Angiostrongylus cantonensis
作者: Chen, K.M.;Lee, H.H.;Lu, K.H.;Tseng, Y.K.;Hsu, L.S.;Chou, H.L.;Lai, S.C.
路光暉
關鍵字: Angiostrongylus cantonensis;Purkinje cells;MMP-9;GM6001;matrix metalloproteinases;cerebrospinal-fluid;tissue inhibitors;nervous-system;gelatinase-b;eosinophils;identification;expression;sclerosis;infection
日期: 2004
Issue Date: 2012-12-07 17:05:14 (UTC+8)
關連: International Journal for Parasitology, Volume 34, Issue 10, Page(s) 1147-1156.
摘要: Angiostrongylosis is a neurological disorder caused by invasion of the central nervous system by developing larvae of Angiostrongylus cantonensis. Purkinje cells in infected mouse cerebellums are small and irregular with degenerative atrophy or partial loss. Ultrastructural changes in degenerative cells included enlarged vacuolar structures and swollen mitochondria within the cytoplasm. The matrix metalloproteinase-9 mRNA which is low in normal cerebellums was expressed in A. cantonensis-infected mice cerebellum prior to Purkinje cell degeneration. Matrix metalloproteinase-9 protein level and enzyme activity increased when the Purkinje cells appeared degenerated. Using immunohistochemistry, matrix metalloproteinase-9 was localised within degenerative Purkinje cells. In addition, when the specific matrix metalloproteinase inhibitor, GM6001, was added, matrix metalloproteinase-9 enzyme activity was reduced by 41.6%. The numbers of degenerative Purkinje cells increased significantly upon establishment of infection but subsided upon inhibition. These results suggested that the expression of matrix metalloproteinase-9 may be associated with degeneration of Purkinje cells in mouse cerebellum infected by A. cantonensis. (C) 2004 Australian Society for Parasitology Inc. Published by Elsevier Ltd. All rights reserved.
Relation: International Journal for Parasitology
Appears in Collections:[依資料類型分類] 期刊論文
[依教師分類] 路光暉

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