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National Chung Hsing University Institutional Repository - NCHUIR > 農業暨自然資源學院 > 食品暨應用生物科技學系 > 依資料類型分類 > 期刊論文 >  Acteoside and 6-O-Acetylacteoside Downregulate Cell Adhesion Molecules Induced by IL-1 beta through Inhibition of ERK and JNK in Human Vascular Endothelial Cells

Please use this identifier to cite or link to this item: http://nchuir.lib.nchu.edu.tw/handle/309270000/132988

標題: Acteoside and 6-O-Acetylacteoside Downregulate Cell Adhesion Molecules Induced by IL-1 beta through Inhibition of ERK and JNK in Human Vascular Endothelial Cells
作者: Chen, C.H.;Song, T.Y.;Liang, Y.C.;Hu, M.L.
胡淼琳
關鍵字: Acteoside;6-O-acetylacteoside;cell adhesion molecules;IL-1 beta;MAPKs;human vascular endothelial cells;low-density-lipoprotein;smooth-muscle-cells;phenylethanoid glycosides;callicarpa-dichotoma;rehmannia-glutinosa;ap-1 activation;expression;inflammation;oxidation;atherosclerosis
日期: 2009
Issue Date: 2012-12-14 09:30:51 (UTC+8)
關連: Journal of Agricultural and Food Chemistry, Volume 57, Issue 19, Page(s) 8852-8859.
摘要: Acteoside, an active phenylethanoid glycoside of many medicinal plants and bitter tea, displays anti-inflammatory properties in vitro. However, it is unclear whether acteoside and similar compounds may inhibit the expression of cell adhesion molecules (CAMs), which plays a role in the pathogenesis of atherosclerosis and inflammation. Here, we found that acteoside, isoacteoside, and 6-O-acetylacteoside inhibited IL-1 beta-activated expression of intercellular CAM-1 (ICAM-1) and vascular CAM-1 (VCAM-1) in human umbilical vein endothelial cells (HUVECs); the inhibitory potency was as follows: 6-O-acetylacteoside > acteoside > isoacteoside. Acteoside and 6-O-acetylacteoside also dose-dependently inhibited VCAM-1 gene promoter activity in IL-1 beta-activated HUVECs. The inhibition of acteoside and 6-O-acetylacteoside on IL-1 beta-activated expression of CAMs was manifested by decreased phosphorylation of extracellular signal-regulated kinase (ERK) and c-Jun N-terminal kinase (JNK). These results indicate that acteoside and 6-O-acetylacteoside may exert anti-inflammatory activities in vascular endothelium by inhibiting the expression of CAMs, primarily through decreased phosphorylation of ERK and JNK.
Relation: Journal of Agricultural and Food Chemistry
Appears in Collections:[依資料類型分類] 期刊論文
[依教師分類] 胡淼琳

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