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National Chung Hsing University Institutional Repository - NCHUIR > 農業暨自然資源學院 > 動物科學系 > 依資料類型分類 > 期刊論文 >  Anti-peroxidation effects of vitamin E on low density lipoprotein and milk fat globule membrane of lactating goats: in vivo versus metal ion challenge in vitro

Please use this identifier to cite or link to this item: http://nchuir.lib.nchu.edu.tw/handle/309270000/133396

標題: Anti-peroxidation effects of vitamin E on low density lipoprotein and milk fat globule membrane of lactating goats: in vivo versus metal ion challenge in vitro
作者: Yang, D.Y.;Chang, C.J.;Peh, H.C.;Chen, M.T.
關鍵字: vitamin E;goats;lactation;lipoproteins;plasma;milk;membrane;peroxidation;transition dairy-cows;alpha-tocopherol;experimental atherosclerosis;antioxidant status;xylenol orange;beta-carotene;e consumption;dietary-fat;oxidation;plasma
日期: 2004
Issue Date: 2012-12-14 09:53:05 (UTC+8)
關連: Comparative Biochemistry and Physiology a-Molecular & Integrative Physiology, Volume 139, Issue 1, Page(s) 11-20.
摘要: Ruminants are animals with mild oxidation risk considering characteristics of their plasma. The purpose of the present study was to determine if surplus vitamin E supplementation further improved their peroxidation status. Four lactating goats (Capra ibex ibex) receiving a single intramuscular injection of 3000 IU D-alpha-tocopheryl acetate were monitored daily for a week. Plasma and milk levels of thiobarbituric acid reactive substances (TBARS) were measured to estimate the peroxidation status of overall body and mammary gland, respectively. Lipid hydroperoxide content of low density lipoprotein (LDL) and milk fat globule membrane (MFGM) were determined both immediately after isolation and after metal ion challenge to evaluate their spontaneous peroxidation in vivo and peroxidation susceptibility in vitro, respectively. The results showed that while plasma and milk levels of a-tocopherol peaked at day 2, the corresponding TBARS dropped to their lowest weekly levels. Content of preformed lipid hydroperoxides in LDL and MFGM remained unchanged (P>0.05) during the study period, while peroxidation in LDL and MFGM on extended exposure to Cu2+ was prevented by vitamin E enrichment. Therefore, surplus vitamin E was beneficial to the peroxidation-resistant mechanisms of the overall body and those specifically within mammary gland of lactating goats. Furthermore, peroxidation resistance of LDL and MFGM to copper challenge in vitro also benefited from vitamin E enrichment despite the fact their endogenous peroxidation seemed unresponsive. The hypothesis that peroxidation of LDL and MFGM of lactating goats in situ, which proceeds with metal ion-independent mechanisms, is minor was discussed. (C) 2004 Elsevier Inc. All rights reserved.
Relation: Comparative Biochemistry and Physiology a-Molecular & Integrative Physiology
Appears in Collections:[依教師分類] 張釵如
[依資料類型分類] 期刊論文

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