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National Chung Hsing University Institutional Repository - NCHUIR > 獸醫學院 > 獸醫學院 > 依資料類型分類 > 期刊論文 >  Protein nitration is associated with increased proteolysis in skeletal muscle of bile duct ligation-induced cirrhotic rats

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標題: Protein nitration is associated with increased proteolysis in skeletal muscle of bile duct ligation-induced cirrhotic rats
作者: Wang, Y.Y.;Lin, S.Y.;Chuang, Y.H.;Mao, C.H.;Tung, K.C.;Sheu, W.H.H.
關鍵字: ubiquitin-proteasome pathway;nitric-oxide synthase;chronic;heart-failure;oxidative stress;degradation;activation;disease;peroxynitrite;malnutrition;inhibitors
日期: 2010
Issue Date: 2012-12-14 12:05:49 (UTC+8)
關連: Metabolism-Clinical and Experimental, Volume 59, Issue 4, Page(s) 468-472.
摘要: Cirrhosis is characterized by skeletal muscle wasting. In this study, the effects of nitric oxide production on skeletal muscle protein nitration and degradation in cirrhosis were investigated. Cirrhosis was induced by bile duct ligation (BDL) in Sprague-Dawley rats for 4 weeks. The BDL-induced cirrhotic rats and sham-operated rats were then injected daily with either saline or N(G)-L-nitro-arginine methyl ester (L-NAME) for 7 days from week 4 to week 5, after which nitrite/nitrate, glutathione reduction, as well as protein nitration, ubiquitination, and degradation were assessed in skeletal muscle. Elevated muscular nitrite/nitrate concentrations, protein nitration, total ubiquitin conjugates, and degradation fragments of myosin heavy chain as well as diminished glutathione reduction levels were observed in BDL-induced cirrhotic rats as compared with controls. Administration of L-NAME for 1 week led to reduction of nitrite/nitrate levels; protein nitration was also decreased in the skeletal muscle. In addition, ubiquitination of muscular proteins and degradation of myosin heavy chain were significantly diminished after treatment of L-NAME. In conclusion, nitrosative stress occurred in the skeletal muscle of BDL-induced cirrhotic rats and may lead to increased proteolysis of muscle-specific structural proteins. (C) 2010 Elsevier Inc. All rights reserved.
Relation: Metabolism-Clinical and Experimental
Appears in Collections:[依資料類型分類] 期刊論文
[依教師分類] 毛嘉洪
[依教師分類] 董光中

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