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National Chung Hsing University Institutional Repository - NCHUIR > 獸醫學院 > 獸醫病理生物學所 > 依資料類型分類 > 期刊論文 >  Cardiovascular effects of herbicides and formulated adjuvants on isolated rat aorta and heart

Please use this identifier to cite or link to this item: http://nchuir.lib.nchu.edu.tw/handle/309270000/136043

標題: Cardiovascular effects of herbicides and formulated adjuvants on isolated rat aorta and heart
作者: Chan, Y.C.;Chang, S.C.;Hsuan, S.C.;Chien, M.S.;Lee, W.C.;Kang, J.J.;Wang, S.C.;Liao, J.W.
宣詩玲;廖俊旺;簡茂盛;張仕杰
關鍵字: cardiovascular toxicity;herbicides;adjuvants;isolated aorta and;heart;rats;nitric-oxide synthase;surfactant;vasorelaxation;induction;paraquat
日期: 2007
Issue Date: 2012-12-14 13:35:03 (UTC+8)
關連: Toxicology in Vitro, Volume 21, Issue 4, Page(s) 595-603.
摘要: Various formulations of agricultural chemicals, including solutions, wettable powders, and emulsifiable concentrates, contain adjuvants of solvents and surfactants in addition to active ingredients. Among these formulations, herbicides are among the most commonly used pesticides globally. Some pesticides have been demonstrated to cause severe circulatory failure in poisoned humans. To clarify the potential risk of herbicides and their adjuvants influence on the cardiovascular system, four technical grade (TG) herbicides and their end products (EP), including paraquat, glyphosate, glufosinate, and atrazine, as well as their formulated adjuvants isopropylamine (IPA), polyoxyethylene alkylether sulfate (AES), ethyl acetate (EA), xylene, petrolium-170 (P-170), and solvesso-100 (S-100), were assessed to determine their effects on isolated rat aorta and heart. The results revealed that the vasorelaxation effects of the herbicide EPs exceeded those of TGs, and atrazine produced more significant vasorelaxation in rat aortas than the other herbicides tested. The formulated adjuvants of IPA did not affect the aorta; however, AES, EA, xylene, P-170 and S-100 caused significant vasorelaxation. Herbicide EPs-induced vasorelaxation was generally endothelium-dependent. Furthermore, the TG and EP of paraquat, and the TG of glufosinate and glyphosate were found to have no effect on the isolated heart. However, the normal twitch tensions of the isolated heart were significantly inhibited by EPs of glyphosate and glufosinate, and by TG and EP of atrazine. Although, the adjuvants of IPA appeared unaffected, however, AES, EA, xylene, P-170 and S-100 caused complete inhibition and contraction on the isolated hearts. These results indicated that the adjuvants of herbicides might enhance hypotension and contributed to cardiovascular disorders during intoxication. (C) 2006 Elsevier Ltd. All rights reserved.
Relation: Toxicology in Vitro
Appears in Collections:[依資料類型分類] 期刊論文
[依教師分類] 簡茂盛
[依教師分類] 張仕杰
[依教師分類] 宣詩玲
[依教師分類] 廖俊旺
[依教師分類] 張仕杰
[依教師分類] 簡茂盛

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