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National Chung Hsing University Institutional Repository - NCHUIR > 獸醫學院 > 獸醫病理生物學所 > 依資料類型分類 > 期刊論文 >  Effect of Immunostimulation by Detoxified E. coli Lipopolysaccharide Combined with Inactivated Propionibacterium granulosum Cells on Porcine Immunity

Please use this identifier to cite or link to this item: http://nchuir.lib.nchu.edu.tw/handle/309270000/136052

標題: Effect of Immunostimulation by Detoxified E. coli Lipopolysaccharide Combined with Inactivated Propionibacterium granulosum Cells on Porcine Immunity
作者: Lo, D.Y.;Hung, C.N.;Lee, W.C.;Liao, J.W.;Blacklaws, B.A.;Chen, T.H.;Chien, M.S.;Hsuan, S.L.
宣詩玲;廖俊旺;簡茂盛;陳德勛
關鍵字: adjuvant effect;immunomodulation;leukocyte function;lipopolysaccharide;Propionibacterium granulosum;sugar-cane extract;pattern-recognition receptor;respiratory-disease;complex;pseudorabies virus;killer-cells;nk cells;pigs;interleukin-2;lymphocytes;strains
日期: 2009
Issue Date: 2012-12-14 13:35:17 (UTC+8)
關連: Journal of Veterinary Medical Science, Volume 71, Issue 7, Page(s) 897-903.
摘要: The aim or this experiment was to evaluate the immunomodulating activities of inactivated Propionibacterium granulosum cell walls and E. coli lipopolysaccharide (PG/LPS) on porcine immunity. Piglets were intramuscularly administered PG/LPS (1 ml/10 kg body weight) once or twice. The function of natural killer cells, lymphocytes and neutrophils and the adjuvant effect on antibody induction by attenuated classical swine fever virus (CSFV) and inactivated Mycoplasma hyopneumoniae vaccination were evaluated. The results showed that the cytotoxicity of natural killer cells and proliferation of lymphocytes in response to mitogen stimulation were significantly enhanced (P < 0.05) in those pigs receiving PG/LPS injection compared with the controls. However, there was no significant effect on the phagocytic activity of neutrophils (P > 0.05). PG/LPS also displayed adjuvant effects with CSFV and Mycoplasma hyponeumoniae vaccines. Moreover, pigs receiving two injections of PG/LPS showed a 20.8% growth enhancement compared with untreated pigs. Thus, PG/LPS caused positive immunoregulation of porcine innate immune system effectors, non-specific activation of lymphocytes and antibody production.
Relation: Journal of Veterinary Medical Science
Appears in Collections:[依資料類型分類] 期刊論文
[依教師分類] 簡茂盛
[依教師分類] 陳德勛
[依教師分類] 宣詩玲
[依教師分類] 廖俊旺
[依教師分類] 簡茂盛
[依教師分類] 陳德勛

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