English  |  正體中文  |  简体中文  |  Items with full text/Total items : 43312/67235
Visitors : 2108589      Online Users : 12
RC Version 5.0 © Powered By DSPACE, MIT. Enhanced by NTU/NCHU Library IR team.
National Chung Hsing University Institutional Repository - NCHUIR > 獸醫學院 > 獸醫病理生物學所 > 依資料類型分類 > 期刊論文 >  Effect of the administration of Lactobacillus paracasei subsp paracasei NTU 101 on Peyer's patch-mediated mucosal immunity

Please use this identifier to cite or link to this item: http://nchuir.lib.nchu.edu.tw/handle/309270000/136086

標題: Effect of the administration of Lactobacillus paracasei subsp paracasei NTU 101 on Peyer's patch-mediated mucosal immunity
作者: Tsai, Y.T.;Cheng, P.C.;Liao, J.W.;Pan, T.M.
廖俊旺
關鍵字: Peyer's patches;Mucosal immunity;Immunomodulation;Probiotics;human dendritic cells;naive b-cells;t-cells;lymph-nodes;cd40 ligand;gut;spleen;milk;persistence;expression
日期: 2010
Issue Date: 2012-12-14 13:36:02 (UTC+8)
關連: International Immunopharmacology, Volume 10, Issue 7, Page(s) 791-798.
摘要: The role of lactic acid bacteria in gut mucosal immunity was investigated by comparing the enhanced effects in the Peyer's patches and spleen of BALB/c mice fed daily with Lactobacillus paracasei subsp. paracasei NTU 101 for 3 to 9 weeks. After feeding with Lactobacillus, the percentage of CD4(+) T cells in both Peyer's patches and the spleen was significantly increased: however, expression of CD 154 molecules, which play a pivotal role in cell-to-cell communication, on CD4(+) T cells and the percentage of B220(+) B cells increased only in Peyer's patches. Compared with systemic serum IgA, Peyer's patch-derived immunomodulation induced higher levels of intestinal IgA(+)-producing cells in the lamina propria. Our data also showed that feeding with Lactobacillus induced stronger CD4(+) T cell-dendritic cell interaction, enhanced CD4(+) T cell and B cell proliferation, and increased IL-1 beta, 1L-10, IL-12, IFN-gamma, and TNF-alpha mRNA expression in Peyer's patches, but not in the spleen. Here, we demonstrate that following Lactobacillus treatment, Peyer's patches exhibited a more distinct capacity to induce CD4(+) T cell-dendritic cell interactions, lymphocyte proliferation, and cytokine secretion than the spleen, and thereby promoted greater intestinal IgA production that could enhance immunosurveillance to prevent intestinal infections or other intestinal pathologies. (C) 2010 Elsevier B.V. All rights reserved.
Relation: International Immunopharmacology
Appears in Collections:[依資料類型分類] 期刊論文
[依教師分類] 廖俊旺

loading Web of Knowledge data....

Files in This Item:

File SizeFormat
index.html0KbHTML363View/Open


 


學術資源

著作權聲明

本網站為收錄中興大學學術著作及學術產出,已積極向著作權人取得全文授權,並盡力防止侵害著作權人之權益。如仍發現本網站之數位內容有侵害著作權人權益情事者,請權利人通知本網站維護人員,將盡速為您處理。

本網站之數位內容為國立中興大學所收錄之機構典藏,無償提供學術研究與公眾教育等公益性使用。

聯絡網站維護人員:wyhuang@nchu.edu.tw,04-22840290 # 412。

DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU/NCHU Library IR team Copyright ©   - Feedback