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National Chung Hsing University Institutional Repository - NCHUIR > 獸醫學院 > 獸醫病理生物學所 > 依資料類型分類 > 期刊論文 >  Analgesic and anti-inflammatory activities of ethanol root extract of Mahonia oiwakensis in mice

Please use this identifier to cite or link to this item: http://nchuir.lib.nchu.edu.tw/handle/309270000/136094

標題: Analgesic and anti-inflammatory activities of ethanol root extract of Mahonia oiwakensis in mice
作者: Chao, J.;Lu, T.C.;Liao, J.W.;Huang, T.H.;Lee, M.S.;Cheng, H.Y.;Ho, L.K.;Kuo, C.L.;Peng, W.H.
關鍵字: Mahonia oiwakensis;Berberidaceae;Anti-inflammation;Analgesia;Carrageenan;Acetic acid-induced writhing response;Formalin test;nitric-oxide;formalin test;rheumatoid-arthritis;inflammation;pain;cyclooxygenase-2;alkaloids;carrageenin;injection;biology
日期: 2009
Issue Date: 2012-12-14 13:36:13 (UTC+8)
關連: Journal of Ethnopharmacology, Volume 125, Issue 2, Page(s) 297-303.
摘要: Aims of the study: This study investigated the anti-inflammatory and analgesic activities, and protoberberine alkaloid contents of ethanol extract of MO roots (MOR(EtOH)). Materials and methods: The analgesic activity of MOR(EtOH) was determined using acetic acid-induced writhing response and formalin test. The anti-inflammatory activity of MOR(EtOH) was determined using the lambda-carrageenan-induced paw oedema model. The protoberberine alkaloid contents of MOR(EtOH) were identified by high-performance liquid chromatography (HPLC). Results: MOR(EtOH) (100 and 500 mg/kg) decreased the acetic acid-induced writhing responses and licking times of the second phase in the formalin test. Moreover, carrageenan-induced paw oedema was significantly reduced in a dose-dependent manner by administering MOR(EtOH) (100 and 500 mg/kg) at 3, 4, and 5 h after the carrageenan injection. The serum levels of tumor necrosis factor-alpha (TNF-alpha) and nitric oxide (NO) of MOR(EtOH)-treated mice were significantly reduced compared with those in the serum of animals administered carrageenan. Notably, MOR(EtOH) attenuated the expression of cyclo-oxygenase 2 (COX-2) and inducible nitric oxide synthase (iNOS) and neutrophil infiltration in paw tissues injected with carrageenan. The anti-inflammatory mechanisms of MOR(EtOH) appear to be related to the inhibition of neutrophil infiltration, iNOS and COX-2 protein expression, NO release, and the decreasing TNF-alpha level in serum. The analytical results showed that the contents of berberine, palmatine and jatrorrhizine were 191.45 mg/g extract, 100.15 mg/g extract and 66.45 mg/g extract, respectively. Conclusion: These experimental results suggest that MOR(EtOH) produced both analgesic and anti-inflammatory effects in mice and may be a candidate for the development of pharmacological agents used in the treatment of inflammatory disorders. Published by Elsevier Ireland Ltd
Relation: Journal of Ethnopharmacology
Appears in Collections:[依資料類型分類] 期刊論文
[依教師分類] 廖俊旺

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