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National Chung Hsing University Institutional Repository - NCHUIR > 生命科學院 > 分子生物學研究所 > 依資料類型分類 > 期刊論文 >  Analysis of flavonoids by graphene-based surface-assisted laser desorption/ionization time-of-flight mass spectrometry

Please use this identifier to cite or link to this item: http://nchuir.lib.nchu.edu.tw/handle/309270000/145723

標題: Analysis of flavonoids by graphene-based surface-assisted laser desorption/ionization time-of-flight mass spectrometry
作者: Liu, Chih-Wei;Chien, Min-Wei;Su, Ching-Yuan;Chen, Hui-Yi;Li, Lain-Jong;Lai, Chien-Chen
Contributors: Wei Chun Wang
日期: 2012
Issue Date: 2013-07-02 10:20:35 (UTC+8)
摘要: Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) is a
simple and fast technique for the analysis of large biomolecules but is not suitable for the detection of low
molecular weightmolecules and compounds, such as flavonoids and phenylpropanoids, mainly due to the
lack of an appropriate matrix. Flavonoids and phenylpropanoids, such as coumarin and its derivatives,
have attracted much attention recently because of their pharmacological activities and putative
therapeutic benefits. In this study, we developed a quick and simple LDI-TOFMS method for the
detection of flavonoids and the derivatives of coumarin. Analytes were spotted onto a matrix of graphenebased
nanoparticles and then analyzed by LDI-TOFMS in the negative ion mode. Analysis of the
sensitivity and effect of different graphene-based nanoparticles including graphene, graphene oxide, and
reduced graphene oxide on desorption/ionization of analytes showed that graphene oxide was the most
suitable matrix. Moreover, we found that graphene oxide sheets of larger lateral size resulted in better
desorption/ionization efficiency. Overall, we showthat graphene oxide is a usefulmatrix for the analysis of
flavonoids and the derivatives of coumarin by LDI-TOF MS in the negative ion mode.
Relation: Analyst, Volume 137, Page(s) 5809-5816.
Appears in Collections:[依資料類型分類] 期刊論文

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