English  |  正體中文  |  简体中文  |  Items with full text/Total items : 43312/67235
Visitors : 2106402      Online Users : 13
RC Version 5.0 © Powered By DSPACE, MIT. Enhanced by NTU/NCHU Library IR team.
National Chung Hsing University Institutional Repository - NCHUIR > 工學院 > 材料科學與工程學系 > 依資料類型分類 > 碩博士論文 >  電解沉積含萬古黴素生醫高分子/ 氫氧基磷灰石/氧化鋯韌化氧化鋁多層鍍層於AZ91植入材之研究

Please use this identifier to cite or link to this item: http://nchuir.lib.nchu.edu.tw/handle/309270000/152976

標題: 電解沉積含萬古黴素生醫高分子/ 氫氧基磷灰石/氧化鋯韌化氧化鋁多層鍍層於AZ91植入材之研究
Vancomycin Contained Biopolymer/ HA/ ZTA multilayer Coatings on AZ91 Implants by Electrolysis
作者: 王天昱
Wang, Tien-Yu
Contributors: 顏秀崗
材料科學與工程學系所
關鍵字: 氧化鋯韌化氧化鋁;氫氧基磷灰石;明膠;甲殼素;萬古黴素
ZTA;hydroxyapatite;Gelatin;Chitosan;Vancomycin
日期: 2013
Issue Date: 2013-11-18 11:39:42 (UTC+8)
Publisher: 材料科學與工程學系所
摘要: 有鑑於鎂合金具生物可降解性、優良的生物相容性及接近骨頭的楊氏系數,故被視為理想的生醫及牙科植入材。然而鎂合金的易腐蝕性卻限制了其在生醫領域的進一步應用;本實驗中,利用電解沉積氧化鋯韌化氧化鋁與氫氧基磷灰石鍍層不僅明顯地將在模擬體液(Hank’s solution)中測得的腐蝕電流由24 μA/cm2 降低到 1.6 μA /cm2 ,也增加了生物活性。接著為了治療及降低手術中感染骨髓炎的風險,再次藉由電解沉積將chitosan-vancomycin-gelatin-calcium phosphate (Chi-Van-Gel-Cap)複合鍍層批覆在試片表面,可得之總載藥量超過2000 μg/cm2並同時呈現兩個月持續釋放的含藥鍍層。考慮到由於骨頭與植入材之間楊氏系數差異所造成的應力遮蔽效應,這種經過以上表面修飾的鎂合金將會是生醫材料在未來一個有潛力的選項。
Magnesium alloys can be ideal materials for medical and dental implants due to their excellent biocompatibility, and degradability. Besides, their Young’s modulus is very close to nature bone. However, the poor corrosion resistance restricts their further applications in medical device. In this study, an electrolytic Al2O3-ZrO2 composite (zirconia toughened alumina, ZTA) coating as the bonding layer for hydroxyapatite (HA) coating, not only obviously improving the corrosion current density from 24μA/cm2 to 1.6μA /cm2 in Hank’s solution by potentiodynamic curves, but also enhancing the bioactivity, is introduced on the surface of AZ91. Furthermore, in order to reduce the probability of osteomyelitis or to treat the related, the chitosan-vancomycin-gelatin-calcium phosphate (Chi-Van-Gel-Cap) composite is also deposited by electrolysis, revealing the drug loading more than 2000 μg/cm2 and the period of sustaining release longer than two months in Hank’s solution. Considering the stress shielding effects resulting from the great difference of Young’s modulus between bone and clinical implants, the surface modified Mg alloys by the above method will be one of the better biomaterials in the future.
Appears in Collections:[依資料類型分類] 碩博士論文

Files in This Item:

File SizeFormat
index.html0KbHTML168View/Open


 


學術資源

著作權聲明

本網站為收錄中興大學學術著作及學術產出,已積極向著作權人取得全文授權,並盡力防止侵害著作權人之權益。如仍發現本網站之數位內容有侵害著作權人權益情事者,請權利人通知本網站維護人員,將盡速為您處理。

本網站之數位內容為國立中興大學所收錄之機構典藏,無償提供學術研究與公眾教育等公益性使用。

聯絡網站維護人員:wyhuang@nchu.edu.tw,04-22840290 # 412。

DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU/NCHU Library IR team Copyright ©   - Feedback