English  |  正體中文  |  简体中文  |  Items with full text/Total items : 43312/67235
Visitors : 2021430      Online Users : 5
RC Version 5.0 © Powered By DSPACE, MIT. Enhanced by NTU/NCHU Library IR team.
National Chung Hsing University Institutional Repository - NCHUIR > 理學院 > 化學系所 > 依資料類型分類 > 碩博士論文 >  1.三氯化鐵在碳-硫鍵交互耦合反應上的應用 2.高效率銅催化炔類與芳香基碘化物之耦合反應

Please use this identifier to cite or link to this item: http://nchuir.lib.nchu.edu.tw/handle/309270000/95002

標題: 1.三氯化鐵在碳-硫鍵交互耦合反應上的應用 2.高效率銅催化炔類與芳香基碘化物之耦合反應
1. Applications of Iron(III) Chloride in C-S Bond Cross-Coupling Reactions 2. Efficient Copper-Catalyzed Cross-Coupling Reaction of Alkynes with Aryl Iodides
作者: 林哲弘
Lin, Che-Hung
Contributors: 李國安;葉鎮宇
李進發
中興大學
關鍵字: Iron-Catalyzed;Cross-Coupling;Copper-Catalyzed;Sonogashira Reaction
鐵催化;耦合反應;碳硫鍵;銅催化;Sonogashira反應
日期: 2011
Issue Date: 2012-08-31 14:09:02 (UTC+8)
Publisher: 化學系所
摘要: 過渡金屬催化交互耦合反應在現今已經成為一個重要的方法來合成碳-碳、碳-雜原子鍵。過去的研究主要著重在鈀、鎳、鈷等昂貴且對環境有害的金屬。在此,本研究使用便宜、低毒性且環保的鐵金屬來進行碳-硫鍵交互耦合反應。使用三氯化鐵/雙螯合磷配位基(Xantphos)作為催化劑,針對文獻中反應性較差的烷基硫醇來測試反應,除了對各種芳香基碘化物都有不錯的產率,這也是首次使用鐵金屬將烷基硫醇進行碳-硫鍵交互耦合反應的例子。
Sonogashira反應是目前最常被使用來合成炔類化合物的方法。然而,傳統上必須使用到鈀與銅或是鈀金屬才能進行這類型的反應,近年來漸漸的轉向使用較便宜且低毒性的銅金屬,但大多需要使用到5-10 mol%或更高的銅與配位基。本實驗研究出使用1 mol%的Cu2O與(1 mol%) Xantphos就可以成功的進行反應,對於各種官能基與高立體障礙基團取代的化合物,都有非常高的產率。
The transition-metal-catalyzed cross-coupling reaction is one of the most powerful strategies for constructing carbon-carbon and carbon-heteroatom bonds. During the last decades, manifold transition metal catalysts especially based on precious metals such as palladium, nickel, and cobalt. Herein we report that iron can be used as a cheap, nontoxic and environmentally friendly metal. The combination of iron trichloride with Xantphos is a very active system for coupling reaction of alkyl thiols with a variety of aryl thiols for the first time.
Sonogashira reaction is probably the most popular strategies for the syntheses of functionalized alkynes from aryl halides and terminal alkynes. The vast majority of the existing protocols involve the use of palladium catalyst. Recent years, copper-catalyzed Sonogashira reaction has gained much attention due to the lower cost of copper salts. However, among the known procedures, 5-10 mol% or higher copper salts are generally required along with high loading of ligands. The second part of this thesis, we describe the combination of Cu2O (1.0 mol%) with Xantphos (1.0 mol%) is a powerful system for this transformation. A broad spectrum of functional groups can be tolerated during the catalysis.
Appears in Collections:[依資料類型分類] 碩博士論文

Files in This Item:

There are no files associated with this item.



 


學術資源

著作權聲明

本網站為收錄中興大學學術著作及學術產出,已積極向著作權人取得全文授權,並盡力防止侵害著作權人之權益。如仍發現本網站之數位內容有侵害著作權人權益情事者,請權利人通知本網站維護人員,將盡速為您處理。

本網站之數位內容為國立中興大學所收錄之機構典藏,無償提供學術研究與公眾教育等公益性使用。

聯絡網站維護人員:wyhuang@nchu.edu.tw,04-22840290 # 412。

DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU/NCHU Library IR team Copyright ©   - Feedback